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Intel develop bioelectric chip for diagnostics
July 19, 2008 - An article on www.techradar.com outlines the premise behind Intel's 'wonder chip' for medical diagnostics. The introduction and link to the full article are below:
 
"Medical diagnostics is a pretty time consuming and expensive endeavour. Testing bodily fluids for various markers of ailments and disease, spooling up those high tech scanners... it all adds to the cost of health care. It's a cost that is becoming increasingly crippling in developed nations.

But what if there was a technology that was not only massively cheaper, but also much faster, as well as more sensitive and more capable? Well, there is.

At least that's what Ilan Levy, one of Intel's big brains at its research centre in Israel (yup, that'll be the same Israeli outfit that saved Intel's bacon with first, the Pentium M, and then, Core 2 CPU architectures).

The basic idea is simple enough to grasp. To use Intel's peerless silicon chip expertise to mass produce a computer chip festooned with diagnostic sensors. "We have developed a single-die chip with 148 different sensors capable of multiple levels of analysis," Levy explains.
 
Thanks to the use of cutting-edge silicon technology, the final production chip is likely to be very small, and hence extremely cheap. That in turn should allow it to be integrated into a low cost, disposable, single-use cartridge that plugs into a larger reusable device.
 
For this usage model, bodily fluids are passed over the chip and the resulting signal or data is wirelessly sent to a control system. Simply replace the cartridge and repeat for each test subject."
 
 

IMEC extends flexible ECG patch to enable arrhythmia detection
July 17, 2008 - IMEC has further extended the functionality of its wireless ECG patch for cardiac monitoring. It added wave analysis software locally on the patch node.
 
The algorithm achieves excellent results for sensitivity and predictivity, and covers a broad range of wave morphologies. The innovative ECG patch is intended to monitor single-lead ECG in daily-life conditions, opening new perspectives for cardiovascular disease management. Besides technological advancements, IMEC also announces National Semiconductor, a specialist in energy-efficient analog integrated circuits, as a new partner within its Human++ program.
 
IMEC’s wireless ECG patch is a wearable, wire-free system easy to set-up. It removes disturbances and discomfort caused by current cardiac monitoring systems. The hybrid system combines electronic assembly on flexible polyimide substrate and integration in textile. This enables flexibility in one dimension and stretchability in the other, which is required for optimal personal comfort. The patch features IMEC’s proprietary ultralow-power biopotential ASIC (application specific integrated circuit) to extract the bio-potential signals produced during the ECG measurements, a commercial microcontroller and a 2.4GHz radio link. The patch can continuously monitor the patient’s heart at a sample rate of up to 1KHz. It sends the results directly to the receiver, or it can analyze the signals locally before sending them. Local analysis reduces the use of the radio, improving the autonomy of the patch. The current autonomy with local delineation is 10 days of continuous monitoring.

The algorithm embedded in the system performs the delineation of the ECG signal, i.e. the detection of the important electrical waves from the heart. The delineator is able to identify P,Q, R, S, and T wave peaks and boundaries. Since the intervals and amplitudes of these waves contain most of the useful information of the ECG, this delineation will provide quick and useful information to the healthcare provider.
 
The delineator on the ECG patch has been validated over all the recordings in the MIT QT database (a database developed by MIT which includes ECGs chosen to represent a wide variety of QRS and ST-T morphologies, in order to challenge QT detection algorithms with real-world variability). IMEC’s ECG patch achieves a 99.93% sensitivity and a 98.28% positive predictivity for QRS detection on 86994 beats. For delineation over 3623 beats, it reaches a 99.83% sensitivity and a 95.08% positive predictivity.
Link to original press release
 

Approval for wireless transmitter that monitors implanted cardiac devices
July 16, 2008 - St. Jude Medical has announced U.S. Food and Drug Administration (FDA) approval of the Merlin@home transmitter, an RF wireless technology that remotely monitors patients’ implanted cardiac devices. The transmitter supports the St. Jude Medical Current RF and Promote RF family of devices and works in conjunction with the St. Jude Medical data management system, Merlin.net Patient Care Network (PCN), to provide complete remote care service for patients and their physicians.

The Merlin@home transmitter’s wireless technology gives patients the additional comfort of having devices automatically checked. Since the transmitter initiates the scheduled follow-up and uses RF wireless telemetry to download data from the device, the entire follow-up procedure is conducted without any direct patient involvement. The only requirement is that each patient remains within range of the transmitter while it reads his or her device. Patients also may initiate data transmissions as instructed by their physicians.

The Merlin@home transmitter is transportable and can be set-up wherever a standard phone line is available, typically by the bedside for data transmission while the patient sleeps. Data downloaded by the Merlin@home transmitter is sent to Merlin.net PCN, a secure, Internet-based data management system, where it is stored for review by the patient’s physician.

“We have simplified remote follow-ups to the extent that they are now something that can be performed seamlessly without interrupting the patient’s day. Patients simply set-up the Merlin@home transmitter; after that, the system handles all aspects of patient follow up, including daily monitoring,” said Eric S. Fain, M.D., president of the St. Jude Medical Cardiac Rhythm Management Division. “The simplicity of the system reduces the chance of patients missing follow-up transmissions.”

The Merlin@home transmitter also monitors cardiac devices outside of regularly scheduled follow-ups. The system can perform daily checks to monitor for alerts about device performance or about patient heart rhythms that may have been detected by the implanted device. Merlin.net PCN can be programmed to alert a physician directly – including an on-call physician outside normal business hours – in the event that the monitored data reveals an episode the physician needs to know about as soon as possible.

“By directly alerting physicians, the Merlin@home transmitter and Merlin.net PCN can help reduce risks associated with cardiac episodes that physicians would want to know about right away,” said Fain. “Without this notification, these events might go undetected for significant amounts of time. Direct notification is one more way to give physicians more control over their patient’s critical health care.”

The Merlin@home transmitter will be available in the U.S. early this fall and internationally in the fourth quarter.


MIT grad student's invention could one day prevent falls
July 16, 2008 - The iShoe insole could help doctors detect balance problems before a catastrophic fall occurs, says Erez Lieberman, a graduate student in the Harvard-MIT Division of Health Sciences and Technology who developed the technology as an intern at NASA.

Lieberman is now testing the iShoe technology in a small group of patients. The current model is equipped to diagnose balance problems, but future versions could help correct such problems, by providing sensory stimulation to the feet when the wearer is off-kilter.

"By doing that we can replace the sense and thus improve people's balance," Lieberman says.

Lieberman and other iShoe team members have applied for a patent on the technology, to be jointly held by MIT, Harvard and NASA. In April, the company won a $50,000 grant from the Lunar Ventures Competition to help with start-up costs.

Lieberman originally developed the technology to help NASA monitor balance problems in astronauts returning from space.

Zero gravity environments wreak havoc on the vestibular system, one of three body systems that control balance. (The others are vision and sensory receptors called proprioceptors, which tell you where your body parts are in relation to other body parts and the outside world.)

"The change in gravity really screws with their sense of balance. They're falling all over the place," says Lieberman, who is a Hertz Fellow and also receives funding from the National Science Foundation and Department of Defense.

The effect usually lasts about 10 days, but NASA tests astronauts' balance for 16 days after their return. Astronauts go into a phone-booth-like box, where they undergo a series of balance tests such as platform shifts and wall shifts.

While at NASA, Lieberman developed a new system for gathering data and an algorithm to analyze the data.

"We've developed the first algorithm that is really capable of not just looking at the pressure distribution of proprioceptors on the feet but also analyzing what that's saying," he says.

Lieberman soon realized that the technology could reach a wider audience than just astronauts. His own grandmother suffered a bad fall several years ago, and he theorized that a balance diagnostic could help doctors catch balance problems before such a fall occurs.

"You have a gradual progression of loss of balance, osteoporosis, and other factors that can lead to the fall," Lieberman says.

The iShoe insole would measure and analyze the pressure distribution of the patient's foot and report back to their doctor. The device could also be outfitted with an alarm that would alert family members when a fall has occurred.

Lieberman and his colleagues are now testing the device in about 60 people, hoping to generate data that will help them create a model to predict the risk of a fall.
 
Link to original press release
 
 

ST+D announces breakthrough device supported by Wellcome Trust
July 9, 2008 - A tiny device invented by ST+D will enable clinicians to assess a patient’s condition irrespective of where they are. The ground-breaking “no wires” technology will also help to reduce patients’ time in hospital and free up beds more quickly.
 
“It won’t matter whether the patient is in hospital, at home recuperating - or holidaying in, say, Spain or South Africa,” according to Michael Caulfield, chief executive of ST+D. “Doctors will be able to click onto a website and review the state of their patients’ health.The breakthrough is based on a disposable adhesive electrode patch worn on the patient’s chest. A small electronic unit with wireless technology is attached which sends processed signals back to the doctor.”
 
The company has revealed that a specific version of the device is now being developed by ST+D and clinically trailed in collaboration with the Royal Victoria Hospital in a project which has been funded by the Wellcome Trust, the UK’s largest medical research charity.
 
This programme-related investment by the Trust is the first of its kind for a private sector business in Northern Ireland. Ted Bianco, Director of Technology Transfer at the Wellcome Trust, said: “Our translation awards are designed to facilitate the development of medical products in areas of unmet need in healthcare. In this way, the Wellcome Trust aims to bridge the gap between a good idea and an innovative tool with the potential to improve the lives of patients. “This device certainly has the potential to change the way doctors monitor their patients’ hearts. Testing it in a hospital environment is the first step to validating the technology and gaining useful insights into how it might best be deployed, both in the clinical setting and beyond.” 
 
Link to full press release

Saving sensor battery energy by 'synchronising' data
July 7, 2008 - New Scientist Magazine outlines the use of 'heartbeat' inspired systems for passing sensor data from node to node being developed by IBM:

"PUMPING" data around a wireless network of sensors - just as blood is pumped around the human circulatory system - could allow the sensors' batteries to last four times as long.

Sensor networks like the ones used for environmental monitoring are usually "tree-like". Their branching structure means information gets from A to B quickly, but means devices have to be turned on permanently to co-ordinate the data traffic.

Now IBM's TJ Watson Labs in New York have come up with a biologically inspired alternative: a "heartbeat" that synchronises the flow of information from node to node around the network. Nodes only turn on when the beat reaches them, saving battery power - but the system is slow because data has to travel all the way around the network."
 
The full article is in issue 2663 of New Scientist magazine, 07 July 2008, page 23
 
 

Self-powered implants for injured knees
July 5, 2008 - A researcher at the University of Southampton has developed a new self-powered sensor to monitor progress during knee operations.

As part of his final year project in his Masters degree in Electromechanical Engineering, which he studied at the University's School of Electronics and Computer Science (ECS), Fauzan Baharudin explored the potential for the use of thick film technology in the development of medical sensors which could be embedded in the knee during surgery.

This new sensor, called Serial In-vivo Transducer (SIT), which uses thick film technology, could measure tendon force during Anterior Cruciate Ligament (ACL) reconstruction.

The ACL is the most commonly injured ligament and is frequently damaged by athletes; in fact it is reported that this is the ligament associated with Tiger Woods' injury.

Fauzan's project was supervised by Professor Neil White in ECS, who in 1991 developed thick film piezoelectric material. This made it possible to produce a sensor that could power itself if it were installed in a device that vibrates and would be ideal for appliances where physical connections to the outside world were difficult.

Professor White said: "Although this work is still in its infancy, our earlier research in thick-film sensors has shown that it is feasible to apply the technology to medical applications such as prosthetic hands. We have also shown that it is possible to harvest energy from the human body using piezoelectric materials and the knee is subjected to very high levels of force during everyday activities. It therefore seems logical to combine the two approaches to deliver a new type of embedded, self-powered sensor.

In Fauzan's project, entitled Assessing the use of thick-film technology in knee surgery: along with energy harvesting in-vivo, he has also incorporated some of this energy harvesting capability into SIT which means that it will be self-powered.

"I chose knee surgery because there has been very little research carried out in this field and I felt a self-powered device could work well in the knee," he said.

Before developing SIT, Fauzan reviewed the existing devices in this field and concluded that due to its flexibility in fabrication, low capital cost, fast lead time and its suitability for use in the body, thick film technology is the best solution for ACL surgery. Assessment of the energy harvesting feature revealed that the device could produce more than enough energy to power itself.

"It remains a mystery to me, given how common knee injuries are among athletes, that devices like ours have not been developed before now," said Fauzan. "A sensible assumption for this is that thick film technology does not reach medical researchers as quickly as it does within the microelectronics community, hence the delay in realising the huge potential in developing in vivo transducers."
 
Link to original press release

Implantable sensor will revolutionise the management of heart disease, say Imperial researchers
July 2, 2008 - Imperial College London researchers have developed an implantable cardiac monitor that supposedly can detect changes in cardiac contractility, hence can function as a continuous (and also wireless) heart failure monitor.
 
The sensor is constructed from silicon and vibrates at a rate which varies according to the pressure inside the heart. Once at home, patients would wear a reader, a miniature device that detects these vibrations through radio pulses, and translates them into precise measurements.
 
Patients would be able view their own readings at home via the reader, while doctors could take measurements by dialling up the reader via a mobile phone or by logging onto a secure internet site. The reader could also be set to automatically send alarms to the doctor if a patient’s heart reading reaches critical levels.
 
Lead researcher, Professor Christofer Toumazou, from Imperial College London’s Institute of Biomedical Engineering, says:
 
“The heart pressure sensor could transform the lives of people living with chronic heart problems and has the potential to revolutionise heart monitoring. At the touch of a few buttons a family doctor could dial up their patient’s heart history and plot pressure trends to better manage their condition and prevent the progression of heart failure.”
 
Sir Magdi Yacoub, Professor of Cardiothoracic Surgery at Imperial College London, has trialled the pressure sensor successfully on animal laboratory models.
 
Link to full press release